Two sample MR report
HLA-DQB1_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.0981955 | 0.2150202 | 0.6560569 |
| Weighted median | 14 | -0.0695834 | 0.0293956 | 0.0179261 |
| Inverse variance weighted | 14 | -0.0506185 | 0.0234116 | 0.0306098 |
| Simple mode | 14 | -0.0728317 | 0.0477461 | 0.1511149 |
| Weighted mode | 14 | -0.0721317 | 0.0471702 | 0.1501813 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.318694 | 12 | 0.9987378 |
| Inverse variance weighted | 2.803433 | 13 | 0.9985552 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0633653 | 0.0910118 | 0.4995472 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005176 | 0 | TRUE | 0.0303505 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
